KUHeS was established in 1991 as the College of Medicine (COM), a constituent college of the University of Malawi with three main roles of training, research and service. The University offers training to not only medical doctors but also other health professionals such as pharmacists, physiotherapists, laboratory technologists, nurses. COM merged with the Kamuzu College of Nursing to become KUHeS during the unbundling of the University of Malawi.